Fundamental Nursing department

Fundamental Nursing

Teacher

Professor, Tomoko Hasegawa, MPH, RN
hasekatz■u-fukui.ac.jp
Professor, Eiichi Ueno, PhD, RN
eiichiu■u-fukui.ac.jp
Associate Professor, Yoshiko Uehara, MSN, RN
uehara■u-fukui.ac.jp
Assistant Professor, Kanae Kitano, RN
kyoshi■u-fukui.ac.jp
Assistant Professor, Rika Tonami, RN
ritonami■u-fukui.ac.jp
Assistant Professor, Yoshimi Demura, MSN, RN
yodemura■u-fukui.ac.jp

If you'll send a mail, please change ■ to @.


Research

Our major research interests are: 1. Tool development for assessment skills, 2. Research method development for generalization of nursing phenomena, 3. Nursing management, 4. Environmental effects on health, and 5.Accuracy of nursing diagnosis. We are also conducting a study for non-smoking educational program for medical and nursing students, and a study for nursing diagnosis accuracy and ability-influencing factors funded by Grant-in-Aids for Scientific Research from Japan Society for the Promotion of Science. In addition, we have a collaborative study with Mihama-cho, Mikata-gun, Fukui on physiological and psychological effects of natural hot-springs.


Keyword

  • nursing education
  • smoking cessation education
  • nursing diagnosis
  • health promotion

Life Science

Teacher

Associate Professor, Reiko Iida, PhD
riida■u-fukui.ac.jp

If you'll send a mail, please change ■ to @.


Research

Identification of age-dependently expressed genes and subsequent investigation of their structures, functions and mechanism of gene expression is one of the most direct approaches in aging research. Furthermore, evaluation of biological or physiological age using age-dependently expressed biomolecules as aging markers has the potential to provide valuable data for diagnosis, prognosis and/or health promotion in old age.

We identified the Mpv17-like protein (M-LP) gene on the basis of an expressed sequence tag obtained by differential display screening of age-dependently expressed genes in mouse kidneys (1, 2). In human, ortholog of M-LP (M-LPH) is expressed as two alternatively spliced variants encoding two distinct isoforms (3). Expression of the M-LPH gene is regulated by a transcriptional repressor, Rhit (regulator of heat-induced transcription)(4, 5). M-LPH has been suggested to interact with H2A histone family, member X (H2AX), ribosomal protein S14 (RPS14), ribosomal protein S3 (RPS3) and B-cell receptor-associated protein 31 (Bap31)(6). A number of previous findings strongly suggest the involvement of M-LPH in mitigation of mitochondrial dysfunction through mtDNA damage (3-6). Our current interest lies in the physiological function and molecular basis of M-LPH.

  • Iida, R., T. Yasuda, M. Aoyama, E. Tsubota, T. Matsuki, K. Kishi. Age-related changes of gene expression in mouse kidney: fluorescence differential display - PCR analyses. Mech. Ageing Dev. 113:135-144, 2000.
  • Iida, R., T. Yasuda, E. Tsubota, T. Matsuki, K. Kishi. Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family. Biochem. Biophys. Res. Communs. 283:292-296, 2001.
  • Iida, R., Yasuda, T., Tsubota, E.,Takatsuka, H., Matsuki, T., Kishi, K. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. Biochem. Biophys. Res. Communs. 344:948-954, 2006.
  • Iida, R., Ueki, M., Yasuda, T. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Mol. Cell Biol. 30:2306-2315, 2010.
  • Iida, R., Ueki, M., Yasuda, T. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Free Radic. Biol. Med., 52:1413-1422, 2012.
  • Iida, R., Ueki, M, and Yasuda, T., Identification of interacting partners of human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage. Free Rad. Biol. Med. 87:336-345, 2015.

Keyword

  • biochemistry
  • DNA polymorphism
  • aging medicine

Health Sciences

Teacher

Professor, Yosuke Shigematsu, MD, PhD
yosuke■u-fukui.ac.jp

If you'll send a mail, please change ■ to @.


Research

In a pilot study of newborn screening by tandem mass spectrometry for inherited metabolic diseases, we provide medical and nursing cares including diet therapy using special formula, life support for avoidance of fasting, and ER medical intervention, specific to the respective diseases. We also provide the special diagnostic tests for a spectrum of inherited metabolic diseases to medical centers in India and China as well as domestic hospitals. The study in diagnosis, therapy, and nursing support for growth disturbance due to various causes is another interest for us.